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Contraindicated (1)pentobarbital will reduce the extent or influence of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is to blame for the development and elimination of cariprazine's Lively metabolites.pentobarbital will lessen the extent or impact of itraconazole by influencing hepatic/intestinal enz